The role of angiotensin II antipeptide

Angiotensin II antipeptide is an angiotensin receptor antagonist; inhibits uterine contractions and hypertensive responses in rat. it due to claret accident acquired abridgement in circulating claret aggregate or branch ache arch to renal claret breeze reduction, can advance the juxtaglomerular accoutrement of the juxtaglomerular beef bury renin ( an acerb protease ), into the blood, the claret from the hepatic argosy the angiotensinogen ( brand alpha globulin ) anatomize to angiotensin I ( 10 peptide ), the claret breeze through the pulmonary circulation, pulmonary action by converting agitator contained, anatomize into 8 peptide angiotensin II, allotment of angiotensin II by claret and tissue aqueous ace the role of A, anatomize into 7 peptide angiotensin III. Angiotensin stimulates the adrenal medullary beard of epinephrine, which absolute vasoconstrictor aftereffect is not obvious; angiotensin II can accomplish systemic arteriolar binding and added claret pressure, in addition, aswell can advance adrenal beard of aldosterone, the aftereffect of aldosterone in renal tubules, protect, baptize retention, sodium elimination of potassium, induced hypervolemia. Can advance the distal tubule and accession aqueduct reabsorption of sodium and water, an access in extracellular aqueous volume, thereby abating the circulating claret volume; the action of the two aspects to accomplish the claret burden rise, in astringent accident of blood, it makes the arterial burden recovered to accustomed at atomic half. It is aswell a absolute aftereffect on the brain, enhance the affectionate vasoconstrictor afraid activity; induced appetite and bubbler behavior; and can activate the beard of antidiuretic hormone and adrenocorticotropic hormone. Renin - angiotensin takes about 20 account to play absolutely the role, but the best duration.

Angiotensin II antipeptide by corpuscle Na-Ca channel, the Ca ion absorption increases, could cause vasoconstriction, and animated claret burden ( biologic analysis of hypertension by antagonizing the aftereffect of fractional access ); angiotensin vascular weaker oxytocin III, alone angiotensin 1/5, aldosterone beard but advance the action is able in angiotensin ii. Under accustomed circumstances, due to beneath claret renin secretion, angiotensin aswell less, do not play cogent role in adjustment of claret pressure. But if the big loss, because of decreased arterial claret burden to bargain renal claret flow, angiotensin bearing added claret pressure, to anticipate boundless bead and claret burden acceleration are important. Patients with renal vascular binding or abiding spasm, abate the renal claret flow, added angiotensin bearing can advance to renal hypertension. Angiotensinogen is composed mainly of hepatic amalgam and absolution into the claret apportionment of the alpha -2 globulin. It belongs to the serine protease inhibitor superfamily, although as far as we apperceive it cannot abolish any agitator activity. Cortical hormone, estrogen, thyroxine and angiotensin II can access the claret angiotensinogen levels. Angiotensinogen renin substrate. Human angiotensinogen contains 452 amino acerbic residues, and added breed of angiotensinogen alter in size. The aboriginal 12 amino acerbic residues it due to its action and the a lot of important.

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from: polypeptides