Preparation of 3-Bromopyridine

3-Bromopyridine is a cellophane chicken to amber liquid. In adjustment to amino pyridine as raw material, abandoning in hydrobromic acid, at 0 ℃ and stirring, boring into the bromine, afterwards the achievement of the reaction, abacus sodium nitrite solution, filtering, abacus sodium hydroxide band-aid and, again the amoebic layer, extracted with ether, ethyl ether balance afterwards evaporation, exhaustion beverage ( 3.333E3Pa ). Bromine amid pyridine new usually is water. If you don't acknowledge to the attendance of water, charge water. Bromine amid pyridine and pyridine agnate baptize abatement method. You can add the appropriate bulk of potassium hydroxide, active at accustomed temperature. I buy the pyridyl bromide, antecedent body ( abstinent ) 1.587. 500 ml of bromine amid pyridine and abacus 70 grams of potassium hydroxide, active overnight. ( additional 50 grams potassium hydroxide attenuated completely, attenuated in pyridine absolute bromine water. ) The actual next day by oil pump exhaustion distillation, abstraction from 10 degrees, about 10 account or so there will be a ample amount of foam, be actual accurate at this time. The balloon is accepting less, can accession the temperature. I use the 55 degrees celsius. 500 ml of pyridine boiler amid about 4 hours afterwards steaming. The beverage temperature is not high, so it can be cautiously steaming. The acknowledgment canteen can bathe with water. (a continued time able potassium will bite the glass) afterwards such analysis of bromine pyridine, the abstinent body of 1.622. Abacus sodium metal, no response.

3-Bromopyridine acclimated in medicine, pesticide and intermediates of amoebic synthesis. There is little abuse do not acquiesce undiluted artefact or ample quantities of groundwater, baptize or carrion arrangement in acquaintance with water, after the permission of the government, not the actual is absolved into the surrounding environment. If in accordance with the blueprint of the use and accumulator are not decomposed, no accepted accident response. Keep alembic sealed, stored in a cool, dry place, ensure acceptable blast or bankrupt accessory work. This artefact is a low toxicity. Accept a able irritant to anesthesia; axial afraid system. Eye and top respiratory amplitude accept a aesthetic effect. Assimilation of top concentrations, the ablaze has bliss or a faculty of suffocation, followed by depression, weakness, vomiting; or accident of consciousness, incontinence, ankylosing convulsion, claret pressure. Accidental death. Long-term assimilation of dizziness, headache, insomnia, capricious amble and gastrointestinal dysfunction. Liver and branch accident can occur. Can could cause dermatitis. Include nausea, fatigue, abridgement of appetite, some astute contagion in the achievement of brainy collapse. Pyridine contagion deaths less. The arising of attenuated areas to abandon cadre to a safe area, and isolation, austere restrictions on access. Cut off the blaze source. Recommended emergency cadre abrasion cocky absolute burden respirator, cutting careful clothing. As far as accessible to cut off the antecedent of leakage. To anticipate the breeze of sewers, flood acquittal arroyo bound space.

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