Gimeracil is an antitumor abettor and a almighty inhibitor of dihydropyrimidine dehydrogenase (DPD).Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the aboriginal footfall in akin recombination for bifold fiber break repair.
Gimeracil is a basic of an articulate fluoropyrimidine acquired S-1. Gimeracil is originally added to S-1 to crop abiding 5-FU concentrations in bump tissues by inhibiting dihydropyrimidine dehydrogenase, which degrades 5-FU. We begin that Gimeracil by itself had the radiosensitizing effect.
Gimeracil inhibits HR. Because HR plays key roles in the adjustment of DSBH acquired by radiotherapy, Gimeracil may enhance the ability of radiotherapy through the abolishment of HR-mediated DNA adjustment pathways.
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