Mevinolin (lovastatin) is also called [3,7-dimethyl-8-[2-(6-oxotetrahydropyran-2-yl)ethyl]-1,2,3,7,8, 8a -hexahydronaphthalen-1-yl] 2-methylbutanoate.
Lovastatin is a member of the drug class of statins, used for lowering cholesterol (hypolipidemic agent) in those with hypercholesterolemia and so preventing cardiovascular disease. Chemical abstracts number: 75330-75-5. The primary uses of lovastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease. Molecular formulae: C24H36O4. It is recommended to be used only after other measures such as diet, exercise, and weight reduction have not improved cholesterol levels.
The effects on melanoma cells and their ability to enhance angiogenesis in a co-culture system presented an opportunity to assess whether Lovastatin act on melanoma cells, HUVEC or both types of cells. The site of this inhibitory effect was determined by measuring steroid products formed in the presence of relevant steroid precursors. Mevinolin (12 microM) inhibited the production of 17 alpha-hydroxyprogesterone from progesterone and that of androstenedione from 17 alpha-hydroxyprogesterone, while 25-hydroxycholesterol to progesterone and pregnenolone to progesterone conversions were unimpaired.
Mevinolin (lovastatin) is a member of the drug class of statins, used for lowering cholesterol (hypolipidemic agent) in those with hypercholesterolemia and so preventing cardiovascular disease. Lovastatin is a naturally occurring drug found in food such as oyster mushrooms and red yeast rice. Lovastatin is also naturally produced by certain higher fungi such as Pleurotus ostreatus (oyster mushroom) and closely related Pleurotus spp. Molecular weight: 388.54.
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